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comment by mk
mk  ·  190 days ago  ·  link  ·    ·  parent  ·  post: mk's senolytic smoothie

The onions are unfortunate. But it is in the neighborhood of a salad with onions and a raspberry vinaigrette.

I picked up some Quercetin tablets, so I could drop the onion and throw a couple tablets in, but I hate supplements as you never know about the quality control. Dropping the onion and adding apple would make for a pretty tasty drink.

The tough thing is the dose. For the human equivalent of fisetin that was used in this study, you need to eat about 2g of the stuff, which means about 14lbs of strawberries. That's probably a toxic amount of strawberries.




tacocat  ·  190 days ago  ·  link  ·  

    That's probably a toxic amount of strawberries.

What could you eat 14 pounds of in one sitting and survive?

user-inactivated  ·  190 days ago  ·  link  ·  

rocks rocks rocks rocks rocks rocks rocks rocks

mk  ·  190 days ago  ·  link  ·  

That is an interesting question. If forced, I think I would choose cheese. It has a high density, and doesn't have too much going on.

kleinbl00  ·  190 days ago  ·  link  ·  

Eriq La Salle once told the story of the 1lb of cheddar he ate on a bet. He ralphed for two hours, supposedly.

14lbs is a little less than three of these:

_refugee_  ·  190 days ago  ·  link  ·  

yeah my thought is that you'd at least be shitting terribly for days

OftenBen  ·  190 days ago  ·  link  ·  

The cheese itself wouldn't kill you but after 14 lb has had it's way with my colon I would beg for death.

_refugee_  ·  190 days ago  ·  link  ·  

Do you like banana? I would recommend banana over apple.

mk  ·  190 days ago  ·  link  ·  

No senolytic flavonoids in banana that I am aware of. Don't mistake this for food. :)

Devac  ·  190 days ago  ·  link  ·  

You could try doing a hot methanol extraction from powdered tablets. It will likely crash-out after a night in a freezer.

mk  ·  190 days ago  ·  link  ·  

How does it improve upon the tablets?

Devac  ·  190 days ago  ·  link  ·  

At worst, you'll be working with identifiable via spectroscopy 'something'. At best, it's going to be quercetin. ;)

You can also extract it yourself from plants. Here a nifty paper on the procedure and references to more specific methods.

kleinbl00  ·  190 days ago  ·  link  ·  

    The tough thing is the dose. For the human equivalent of fisetin that was used in this study, you need to eat about 2g of the stuff, which means about 14lbs of strawberries.

How... often must one eat 14lbs of strawberries? Because I'll be honest I've never seen a recipe that makes me question the LD50 of a fruit before.

mk  ·  190 days ago  ·  link  ·  

I have a pal that just went for it with fisetin supplements. He reported no observable ill effects, except for itchy skin after eating more than a bottle. He has 30 years on me, and is in senolytics R&D. Don't try this at home.

I'm going to give it more time, and do some experiments (in the lab) myself before replacing a smoothie.