Appalachia is a bit of a gamble, what with coal as an industry dying a painful death and lumber and steel not being what they used to be. The mid-west is almost as inexpensive as francopoli points out and probably has a better economic safety net, Detroit being a depressing statistical outlier. That book is going on the list though. It's a good thing summer is coming around, I'll be able to spend plenty of time outside catching up on everything you're recommending me. I don't know what the rest of the economy looks like out in the Great Plains. Regionally though, it's appealed to me a ton, if only because it has such a beautiful landscape. I half think francopoli should take some of his equipment out there for a vacation sometime for star gazing. The lack of light pollution from the cities coupled with a clear night would make for some great shots. An honest part of my unhappiness comes from city living and while I'd love to get away from it, I wonder if some place like rural Wyoming might be a bit extreme. On the other hand though, if I could find myself a decent paying job out there, it might be worth it.
The fact that you want to move deeper into the Flyover States indicates beyond a reasonable doubt that you should follow your heart, not mine. given my druthers...
Two weeks. Deadliest road in Canada to get there. Primarily because it's a double-yellow 2-lane for about 200 miles and it all looks like this And you have to break the speed limit because it's so fucking fun and then you swing wide into oncoming traffic and oops there's a logging truck.