It would have to be Hugo Weaving as Haskell Moore in Cloud Atlas, or Hugo Weaving as Tadeusz Kesselring in Cloud Atlas, or Hugo Weaving as Bill Smoke in Cloud Atlas, or Hugo Weaving as Nurse Noakes in Cloud Atlas, or Hugo Weaving as Boardman Mephi in Cloud Atlas, or Hugo Weaving as Old Georgie in Cloud Atlas. Actually, definitely either Nurse Noakes or Old Georgie. Cloud Atlas really cemented my love of Hugo Weaving.
I'm not sure how, but this movie isn't even on my radar. I just saw this preview and it looks bad ass. I take it you've seen the film?
Sounds like it is worth a look, if nothing else to see Tom Hanks in something "unusual". I have a hard time watching him sometimes and then others I really enjoy his work. Sounds like an interesting cast.
It only just came out a few weeks ago here in Ireland (having been out in the US for several months) and a friend of mine who loves the book got me interested in seeing it. It turned out to be fantastic. I really loved how you'd see a character and then think "Wait a minute... Is that Hugh Grant? That is Hugh Grant!" We watched the movie and then stayed up till five chatting, and even though I had an appointment at ten it was well worth it.
I would not have thought they could have done justice to the book (which I enjoyed quite a lot), but they really did. The two are very different in many ways, but both are really good. A more literal translation of the book to film just would not have worked as well.