I've seen a thread on reddit, featuring an image of a half-naked girl covered in nitrous bulbs — completely wasted. From reading the comments, it seems nitrous is/was really popular with high school kids. The way the kid in the picture looked, though, I wouldn't recommend that.
I doubt it'd be fun to do without friends. And to be honest, I've got other means of finding enjoyment with friends, but to each their own, I suppose.