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The tricky bit is the tensile strength of your structural members goes up linearly with cross-sectional area while your surface area goes up as the square and your volume goes up as the cube. The same thing that keeps ants smaller than elephants rewards aircraft that remember they're not whales. It's not so much a "stability" problem per se it's the fact that a big plane has to deal with more forces and less unity of strength which requires more care.