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comment by Killerhurtz
Killerhurtz  ·  3463 days ago  ·  link  ·    ·  parent  ·  post: World’s first head transplant patient schedules surgery for 2017

Awesome - though I have two more things to say:

First, on a HUMAN they haven't "repaired" a fully severed spinal column - because 99.99% of the time, because of the sensitivity of the nerves, there's massive inflamation that happens - and it cuts off blood flow, preventing healing and further damaging/killing nerve cells. BUT they HAVE healed spinal cord injury, in rats... using something very close to blue food dye. And they already know it's non-toxic (except probably California which says it's carcinogenic, as always) because of how much of it humans consume on the regular. The only side effect (because it was an intravenous injection - because as it turns out, not only does blue food dye help prevent nerve inflammation, but it also crosses the blood-brain barrier) is that it turned the rats blue - which I'm not convinced will be as much of an issue in humans, and can probably be counteracted somehow. Sources for this: 1, 2, 3

Second, you made me realize something. Barring some incompatibility we discover,

    for external parts you want male to male

this does not have to be true. If there's enough donors, I can entirely see a market for transgender body-swap, which would have several advantages over current gender reassignment surgery - most notably working sexual organs of the desired gender (if everything goes well).





user-inactivated  ·  3463 days ago  ·  link  ·  

    this does not have to be true. If there's enough donors, I can entirely see a market for transgender body-swap, which would have several advantages over current gender reassignment surgery - most notably working sexual organs of the desired gender (if everything goes well).

My statement about "male to male" or "female to female" parts has nothing to do with gender or genitals. Men have thicker muscles, stronger tendons, more blood vessels and a different physiology than women. This is a very real issue in things like heart and lung transplants. 90% of the people on the heart transplant list are men, and men cannot use female hearts. Organ donors are split roughly 50-50; then you have to get into the tissue and blood type matching etc. Another example is female lungs don't fit into a male chest cavity. It works the other way as well, male hearts are not a good fit for female donors with a significant greater risk of rejection. Even kidneys, where the new kidney is inserted alongside the existing and the 'bad' organs left in the patient, need to be inserted into the same gender recipient as donor. The kidney thing shocked me. Kidneys sort of just sit there and if there was any organ that did not care about the size or gender of the recipient it should be kidneys.

Article on hearts here

Paper on Kidney gender mismatch here

Composite tissue allotransplantation is fascinating. There is so much going on during the transplant and it all has to match and line up. The surgeries are long and done under a microscope to meld together the tiny blood vessels, stitch the tendons together and fuse the bones while preserving the channels for the bone marrow so that it does not die in the recipient.

Killerhurtz  ·  3462 days ago  ·  link  ·  

That's actually a very interesting phenomenon - thanks for the info! (Biology is fascinating...)

user-inactivated  ·  3462 days ago  ·  link  ·  

One of the first things I did at this job was editing a video of a replant surgery; kid took his own arm off with a chainsaw. You learn things as you go along.

Killerhurtz  ·  3462 days ago  ·  link  ·  

Yeesh. SCIENCE!