I don't take it personally, unless it's actually personal (i.e, directed at me). But still, I'm going to call it out when it makes sense to do so, especially on social media forums like this, where I don't have to suffer the extra emotional impact of having this sort of conversation face to face. My voice, and the voice of millions others, won't be heard otherwise.
I have a disability that is the subject of mockery in mainstream society. Can you imagine if it were the same for cancer or AIDS? It USED to be the same as AIDS, but we fucking stopped, didn't we? One out of five people with my disability, which is hereditary, die because of it. It killed fucking Robin Williams. People like me are highly functional, higher than average, sometimes, and you use the same words to describe my disability as you do to call into question the judgement of your rivals.
Do you not see how this makes life far more difficult for me?