I like the ideal of hubski put forward in this post. I've used reddit to find intelligent discussion of topics important to me, but I don't love the idea of subscribing to individual users to find that discussion. I don't want to join a "twitter with more characters". What do hubski users have to say about that? That said, I can also adjust to new formats when necessary. Which users should I follow for world news, astronomical and space discussion, video games, US legal issues, US politics, EU politics, current book releases, folk and punk and ska and jazz and blues and pop music, sci-fi/cyberpunk, and Dungeons & Dragons?
You actually don't have to follow users at all. You can follow only tags if you wish. I'd suggest following tags like #uspolitics #jazz and #rpgs there you will see posts that share other similar tags that you might like to follow. If you find a user submitting to a tag that seems to post very good content, you might want to follow them, but it's not necessary.