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comment by thundara
thundara  ·  3673 days ago  ·  link  ·    ·  parent  ·  post: Blood of 115 yo woman hints at limits of life

They're also an excellent link to cancer. If you start propping up the cells that were supposed to die, you're going to start seeing mischief. If you start injecting "fresh" ones...well, that's still to be seen.





mk  ·  3673 days ago  ·  link  ·  

That's an actual proposal b_b and I put together: take bone marrow in your youth, freeze it, then autologous transplant back when you are old.

thundara  ·  3673 days ago  ·  link  ·  

How is that better than metaphorically cutting the end of a string and tying it to the other end of the string?

b_b  ·  3673 days ago  ·  link  ·  

Because the string regenerates itself readily in youth, but for whatever reason ceases to do so in old age.

thundara  ·  3673 days ago  ·  link  ·  

    Because the string regenerates itself readily in youth, but for whatever reason ceases to do so in old age.

But does this string regeneration itself carry a limited life? Perhaps hard to discuss this without talking about integrals of strings...

I guess a better question might be: Is it extrinsic or intrinsic factors that prevent string regeneration? Are the oldie stem cells old because they were damaged? Or because they were pre-programmed to wind their division down over the years?

My stem cell knowledge is poor =(

mk  ·  3672 days ago  ·  link  ·  

The hope, and my hypothesis, is that the young marrow can partially replace and possibly recapitulate functionality lost over time. The marrow contains stem cells for multiple systems, including blood and bone, so the thinking is that these cells can create a genotypically, and hopefully phenotypically, younger progeny.

Transplanted marrow cells can expand and replace after ablation from chemotherapy, so the potential is there. Since it's your own cells, your body shouldn't reject them, and hopefully, they will slowly replace the older cells. Of course, the body might signal them to do otherwise, but to the extent that it doesn't, there may be benefit.

I call it 'temporal transplantation therapy'. :)

water  ·  3618 days ago  ·  link  ·  

That sounds like bone crushing surgery for someone in the latter stages of life.

b_b  ·  3673 days ago  ·  link  ·  

Well, that's why we want to do the experiments :)

OftenBen  ·  3670 days ago  ·  link  ·  

... Someone please start doing this.