Oh I get it, so you mean God as an essence, not the religion's interpretation of his character or what not. Well. Now I remembered a Futurama episode where Bender got lost in space and found himself in this weird cosmic-creation, who had conversations with him about stuff. The thing is, that you can explain anything with just "God", but science finds more and more ways to actually measure unknowns and describe them. Even the dark matter has certain patterns of it's being because of the gravity readings around it. It's really hard to think of it as if it had it's own mind, or if it were a God. There might be something in it, like another form of life or reality, which we can't even wrap our minds around. But God as if "creator of everything and reason behind everything" not really.

And as for the "universe is trying to tell us", as if "See how unknown and weird it is? Well leave it alone, you shouldn't fuck with it" :). The universe doesn't tell us anything: it just exists. We're just humans who are curious and want to study everything around them so we take a look and start "poking it with sticks".