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- Marijuana may be one of the safest intoxicants known to man—in thousands of years of unregulated use, there has not been a single known fatality attributable to overdose. However, the system by which millions of Americans obtain their pot is deadly and growing deadlier. Mexican cartels have long supplied heroin, methamphetamine, and cocaine to the United States, but marijuana is the most widely used drug in the United States, and the cartels are in a murderous frenzy to provide it. Since 2006, approximately 50,000 people have been killed in a gruesome war to control lucrative smuggling lanes into the United States.