My nook is a wonderful thing. I love being able to look up unfamiliar words by tapping and holding. Its the first thing I miss reading a print book.
What I've found surprisingly obnoxious now-a-days is holding the book open. That's actually kind of disappointing to me somehow because I LOVE the physical object and actually owning a thing. But I bought Anathem in print a few weeks ago in paperback. It's a 900 page monster and after 30 minutes of prying it open, I went online and (be it legal or not) pirated the E-book so I could read it on the nook.
I do wish publishers would get on board with that whole thing too. My idea? Buy the book at the bookstore for $15 OR go online and get it for $10 as an E-book. OR buy the book for $17 at the book store and get a code printed on the receipt to download an E-book version when you get home.