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Yeah, I was talking to a proteomics guy about variance in protein activity across a tumor. He was saying that if you took samples from far apart on a tumor, you saw almost no correlation in activity. In fact, if you took samples from right next to each other on a tumor, you saw almost no correlation in activity. Cancer's weird, miRNAs are weird, and now I'm going to throw "exosomes" are weird into that bucket, too. Still, food for thought in all of the above.But, for some like glioblastoma, there are a number of paths to a similar malignancy, and any treatment will only hit a subset.