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comment by BlackBird

Or him having a tongue-in-cheek dig at the Church going "*It's all in your head*".

There's a good analysis of Michelangelo's work and a couple others as well. Rafael's seems to be a bit of a stretch, but David's Transfiguration bears a good resemblance to a cross section of the brain too.

Still, The Creation of Adam is most definitely a brain in disguise, I am in awe at Michelangelo's ability to craft it without the holier-than-thous really realising.