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There has been some relatively recent (earlier this year) work that suggests that microglia mediated degradation of synapses is a hallmark event in AD, possibly antecedent to tau or AB deposition. My work (unrelated to AD) has recently had me focused on microglia, and the more I learn about them, the more I'm (1) fascinated and (2) dumbfounded.aducanumab's microglia-mediated activity could account for the antibody's ability to remove plaques, rather than just to slow further Aβ accumulation