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When it stops being fun, when it becomes something you put too much effort into whatever it is for the reward, and for me personally when I start to feel too defined by something that means it's time to quit. The latter is a problem where I sometimes become too consumed by one sport, hobby, or other and eventually feel it has become too much of my being. It's time to quit when the absence of what you're quitting is preferred to the continued presence of it.