I'm interested to see if you decide to do so over time. In your use case, I could see the point I made to Aeiri applying:
One thing I have also considered is how this plays into scaling. The conventional wisdom says that as tags grow more popular, the ratio of quality content will fall. However, what if I really want to get great #politics posts even after hundreds of users are submitting to it? Previously, I would have had to follow #politics, and filter an ever-increasingly large swath of users (in entirety, not just their politics posts) to cull out the chaff. It is a race, that eventually I would lose. Now, I have the option to browse #politics, find the best users submitting to it, and follow their personal politics tags. With this approach, my politics feed doesn't degrade over time. Of course, I need to work if I want new voices, but I won't have to be constantly filtering users to have a quality politics feed.
Of course, for quieter tags, I can take the opposite approach: filtering a personal tag or two might be all it takes to keep the overall tag quality, and I need't filter out those users wholesale. In that respect, we now have two kinds of filtering: content-specific, and user-specific.
The presentation is wanting with regards to the repetition, however. It's pretty clear there is some consensus there.
I will also say I had to click around for 20 minutes to figure out where my ignored domains were.
Good point. That info should be in the same place where the moderation tools are when you visit someone else's profile.