Am currently halfway through a 10 Hour Dr., and I would much rather be on a train. That said, there is no doubt that train travel in the US pretty much sucks. But here are some tips on how to make it more tolerable: http://hubski.com/pub?id=38684
Edit: it is amazing how beautiful West Virginia is to drive through. Then you go over this gorgeous bridge, and you see a sign for Ohio and the other side immediately sucks. Ohio is really difficult to drive through, it takes about 70% of the trip and it's flat, and quite barren.