Personally I use KeePass to generate a different password for everything i sign up for, usually 60 characters in length containing everything from letters to numbers to symbols. If anyone happens to get access to one of my accounts there is zero chance of them using that to gain access to something else. Above and beyond that I have four different email accounts. A gmail account for Play Store and Google rubbish, a gmail account for Facebook and only Facebook, a yandex account for forums and junk mail and one more yandex account for personal use.

When I put it into writing like that it seems like a hell of a complicated process but honestly it's not. If you use an email client like Thunderbird, it doesn't matter whether you have one email address or fifty thousand million email addresses. And if you use a password safe like KeePass every account that you ever need to sign into is a click and master password away. I would highly recommend. Also, avoid password safes that store your stuff online, that kinda defeats the purpose.