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When you have a very expensive hammer... My favorite studies are those that aren't technologically fancy, but test a big idea. This is the study that I am most proud of to date. b_b and I just used luciferase assays for miRNA activity to demonstrate functional exchange of miRNAs between cells. The trick was that we expressed C. elegans miRNA in one population, and had a luciferase reporter for it in another. Super short and sweet, and nothing fancy involved.