Over the last year, off the top of my head?
Move all the employees to SF per the VCs.
End the outside vendors on Redditgifts and monetize that marketplace as a reddit Inc space.
Drive popular, yet "offensive," content off the visible parts of the site. This is why /r/cutefemalecorpses and /r/coontown still exist.
End salary negotiations. The conspiracy theory is that this is to lower payroll costs.
Then there are the mod's frustrations of a lack of support from Reddit Inc employees as to what is brigading, spamming, how to deal with trolls, etc.
That is off the top of my head. I bailed on Reddit last year and don't go there anymore, but I do note the drama when it leaks out to the normal spaces on the Internet. Example, Forbes, CNN, BBC, Guardian have all been running Reddit stories.