I had issues with the NVIDIA drivers, or rather, swapping over to the libre ones; after that was issues with getting Steam to work, which mostly required launching, checking which library was reported missing, figuring out which package to download, rinse & repeat. I had a few issues with Ruby and various frameworks/gems and a few issues trying to get my printer/scanner to function (it did... then didn't and then wouldn't work on any other system so I evidently locked it somehow, fixed it in the end but still!) Like I said, it just feels like Fedora doesn't really get a look in, every bit of media I see about doing something on Linux is for Ubuntu; yes it mostly is cross-compatible, but trying to work out what the RPM equivalent to a package is can be tedious.