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It's not like there aren't studies on chronic toxicity after approval, just not before. It's a contended topic, but to be fair, you don't do any studies on the chronic toxicity of food when you cross a new strain, either, and often that generates much more complex genetic changes. Tangent: I learned recently that big ag companies have taken an interest in microbiome research. Supposedly they've become more pro-active because it would be fairly straightforward now to link an outbreak of antibiotic-resistant infection to farm strains if one turned out to exist. Then the blame would be on them for ignoring decades of research and they could be liable for damages / deaths.