I got a question for ya, mk: I'd learned previously that cancer progression is usually associated with a few traits that must all be gained together for a tumor to grow and metastasize. To what extent are the authors here referring to exosomes making the surrounding cells cancerous (i.e. dividing a lot, immortal, avoiding apoptosis) versus promoting just the traits associated with cancer metastasis (i.e. break down the ECM holding the tumor in place)? They talk about PTEN and HOXD10 being targets of the miRNAs... I know the former holds back cell division, but the latter I've never encountered before. Is there still merit to their claim of "tumorigenesis" even if those surrounding cells don't have the ability to survive forever by re-lengthening their telomeres? Without that, I'm picturing a lot of cell growth followed by a lot of cell death around the tumor...For example, miRNA-21 and -10b were upregulated (4.6- and 2.3-fold, respectively) in cancer exosomes-treated MCF10A cells. miRNA-21 and -10b have been implicated in breast cancer progression and metastasis