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The plummeting street price of many illegal drugs over the last few decades is compelling evidence that interdiction has not done much to stem supply. Drug overdoses have increased almost six-fold in the last thirty years. They are now the leading cause of accidental death in the United Sates, having surpassed motor vehicle accidents for the first time in 2011.
But, this is by and large due to a huge increase in prescription drug overdoses: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6101a3.htm Since 2003, more overdose deaths have involved opioid analgesics than heroin and cocaine combined (Figure 2)