Armchair scientist mode: The Good: - Structural bio teaches the idea: show it, move it, block it to prove a mechanism. They do all of it, so I don't doubt it as a mechanism for the effect The Bad: - Mice ain't human. Can this happen in humans? Will it happen if I sprinkle splenda on my tea every day? Do I need a suppository to see the effect? What's the evidence to support the presence of this effect already in humans? - Comparisons to other diets (Paleo?), does it give the same effect? How long is this effect a problem for? It's interesting, but "more results needed", a good reason to run a larger randomized controlled trial, but not to immediately call your lawyer and start shoveling powdered sugar down your throat. P.S. Feel free to call me on my bullshit, I only read the abstract