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Genetic manipulation has gotten better in recent years. Gene therapies for two genetic diseases are already in the clinical trial stage. And that's using methods that are already going out of date. The bigger problem is figuring out where in the DNA to poke, since most diseases / features aren't as simple as a simple base-pair swap.in vitro's brutal; most people don't realize that. It sucks for mom and it's hell on eggs. That's just gettin' 'em to cook. Gene targeting is a stone cold bitch and it's low-yield. I don't know the numbers but when your principal method involves bioballistics you're not looking at 100%.