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    During the first half of the 20th century, M. bovis is estimated to have been responsible for more losses among farm animals than all other infectious diseases combined.

Damn, neither had I. Modeling TB transmission in Bovine to test the idea of killing off / segregating infected cattle was just one of the first examples systems biology that I learned.

Edit:

    Oh nice, just as antibiotic resistant TB is on the rise.

You'll note that the wikipedia page lists "culling" as the treatment.