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I don't think I've ever had a published unit that left me feeling completely fulfilled and satisfied. Naturally, by the time the draft is coming together, you start to question little bits here and there, think about the things you could do to make it stronger, wonder if a follow-up experiment could pull the rug out from everything, and so on. Then there's always the push from you boss or advisor or the real-world realities of academia to just wrap it up and put it out there. It's just the pace of research.