Awesome concept. Sounds like it's worthy of at least one novel, though I can see it working in an interesting fashion if it were multiple novels where each had a different main character that it followed.
Since you mentioned werewolves and Inuits, I'm reminded of 30 Days of Night... about vampires, but I like the idea of werewolves in a similar environment better.
Though I'm guessing that by it's nature, the tone you're striving for is a more action than horror? If so, I can also really see it working as a comic book or graphic novel.
Well, like I said it is still pretty early in development, so I was really unsure of the direction. I really only have a few speciations of vampire, werewolves, and some ghosts. This seed came about maybe a few months ago. I actually imagined it a graphic novel too sometimes.