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comment by mk
mk  ·  3927 days ago  ·  link  ·    ·  parent  ·  post: An engineered bacterium able to copy DNA that contains unnatural genetic letters.

    If you have too many of these bases not hydrogen bonding, the DNA's going to fall apart.

IMO they don't seem to suggest that a future organism's DNA would be comprised by these specific base pairs. The primary achievement here was getting replication and retention of the artificial pairs, which is no small feat.

They do have a relevant previous article: Structural Insights into DNA Replication without Hydrogen Bonds