I have become increasingly interested in senescent cells. These are cells that have shut down due to damage, but have not gone through apoptosis. They are often described as zombie cells, as they don't die, and have a deleterious effect upon surrounding tissue. There is an increasing amount of evidence that senescent cells play a role in age-related decline, and that clearing them extends healthy lifespan. IMHO senescent cells are part of Mother Nature's way of making sure you die on schedule.

Some molecules have senolytic properties, meaning they clear senescent cells (typically inducing apoptosis in them). One such molecule is fisetin, which is a naturally occurring flavonoid. Here's an article with a pretty striking effect of fisetin in mice:


Never trust just one article. However, there is a growing heap of evidence that these senolytic flavonoids are a good thing to include in your diet.

Anyway, for the hell of it, I decided to see if I could make a smoothie that was stacked in senolytic flavonoids. This is what I came up with:

That's strawberries (high in Fisetin, also has Quercetin, Kaempferol), persimmon (has Myricetin, Fisetin), onion (High in Quercetin, also has Myricetin, Fisetin, Kaempferol, Luteolin), and parsley (high in Myricetin, also has Fisetin, Quercetin, Kaempferol, Luteolin). I was guided by this paper:


It's awful. I think I am going to add oranges or apples. They also have a good amount of flavonoids, and might make this thing more palatable.


Uhhh... you could make some onion & parsley salsa and wash it down with a strawberry-persimmon smoothie.

See it's shit like this that makes the rest of us ignore you when you espouse the benefits of Soylent. You're like one step away from being sane but "maybe strawberries and onions will taste bad together" is like this insight that you're too focused to accomplish. ;-)

posted by mk: 158 days ago