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"our knowledge is imperfect, therefore we'd best not tamper"
Heck no, I think we should continue to tamper. I'm all about tampering and messing with what we don't understand. I enjoy the scientific pursuit after all. But I think we can do a lot more tampering in animals before we do it in a human. I would never suggest that we need to have perfect knowledge before we do it. (Do you seriously think I'd be so unreasonable?) But our knowledge right now is piss poor. We can easily improve on it, and we will.