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- The cause(s) of HPPD are not yet known. The most current neurological research indicates that HPPD symptoms may manifest from abnormalities in CNS function, following hallucinogen use.[5][6][7] One theory derived from this research is that inhibitory mechanisms involved with sensory gating are disrupted.[8]
In some cases, HPPD appears to have a sudden onset after a single drug experience, strongly suggesting the drug played a direct role in triggering symptoms.
That would be awful. I've only had one experience that I considered to be a flashback, and I was going without very much sleep at the time.