I used to be a heel-striker, but when my knees starting acting up I decided to try a minimalist shoe and change my running form. I bought Innov8's, 6mm heels to start last August in anticipation of a half marathon in early November. Knees felt great, but I tore a calf muscle, setting me back nearly 3 weeks. I tried gradual increases, but simply could not get my calves in shape in time, ended up running the half marathon with my old shoes.
After the marathon, I began using the new stride again, and it has taken an incredibly long time to build up the different muscles used, but my knees are doing well.
It's probably to each their own, but I do believe the mechanics of running on the balls of your feet offer something.