I like 'The Knights of the Night.'
They're just serious enough to make their games super enjoyable, and they take a lot of time to talk about systems and storywriting before their games, as well as a detailed post-mortem upon the conclusion of a chapter. They have a massive backlog of episodes, my favorites being their Dresden Files campaigns.
Just realized you probably meant vidya rather than tabletop.
Mostly it's the Trinity Force podcast for League of Legends, though at one time I was really into Painkiller already, even though I've never been deep into Call of Duty.