I just got my newest box up and running and I'm thinking about getting myself an account and trying it out. I just don't want to go through it only to discover it's a hassle to make things work.
I played Baldur's Gate II: Shadows of Amn from GOG on my Arch laptop.
It actually isn't ported to Linux, it just runs natively in WINE, which was kind of a bummer to see, but it works fine, so it's no big deal. I'd actually imagine that most of the old isometric cRPGs from GOG run in WINE, but I guess I can't be sure.