I'm so conflicted here. This is rant-worthy stuff, and I also agree. Hell, we've paid for these kind of analysis. I would love to hear some specifics, however. Biology is dirty, confusing, and complicated. I think textbooks do an incredible amount of harm by drawing diagrams of cellular systems as if things actually worked like they suggest. Genes don't do things, and proteins don't have specific functions. Journals love to say that they do, however. Everything is contextual and a part of multiple feedback loops. Bioinformatics can be valuable when applied in that light. However, using bioinfomatics to find parts of an intricate machine is dumb. I want to know what Fred Ross' expectations are. That said, most bioinformatics is based on unjustified expectations.