I'll actually tell you one thing, the best place to put the game down (once) and get some sleep is between episodes 2 and 3. You're not going to want to put it down during the craziness that is 3-5, and generally you'll need a nap in between.

I just got to the end of episode 2 for the fourth time in a row and I know (because of past experience) that I've lead the story down in about 4 different places that I've never experienced before, so it will be interesting to see how they play off each other. There's already been dialogue I've never heard before and the real choice impacts haven't occurred quite yet.

It's also interesting to be able to figure out how everything plays off each other I guess with multiple playthroughs. Combining X with Y choice can cause outcome 1 of 3, let's try to get outcome 2 next time around, etc.

There are also entire locations that you will not be able to go to every time. There's no reason to because the plot doesn't develop that way for you. This game is so intricate and the sheer quantity of meaningful items laying around is staggering.

I do have to say this is probably a masterpiece.