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b_b  ·  3093 days ago  ·  link  ·    ·  parent  ·  post: Five Nobel Prize Winners Back Longevity Pill

    Past studies have found boosting this enzyme through calorie-restrictive diets has helped extend the lifespans of mice, but it hasn't exactly been tested out on humans.

Nooooooooooooo! Past studies have found that calorie restriction extends life and boosts this enzyme. Let's not imply causation where we don't have evidence for it. The fact is that calorie restriction likely extends lifespan through a multi-modal process that includes reducing systemic inflammation, for example. I'd bet a large amount of money that any single enzyme is a small piece of the puzzle. Studies on transgenic mice have been interesting, but unconvincing. Really, it's still a lot easier and cheaper to walk more and eat less than to take a supplement that probably doesn't work every day for the rest of your (indeterminately long) life.