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Don't use Adblock Plus. Use uBlock Origin.
Adblock Plus has a strange design flaw that they would have to rewrite the script over. Basically it uses one giant CSS document to strip out the ads, and it uses the same CSS document on all websites you view. It can cause some serious performance issues with your browser.
uBlock Origin uses the same blocklists, yet splits it up into smaller chunks of relevant CSS for each website. It has all the same features and then some, and also has major performance gains.
Honestly if you really want to lock down your browser, Ghostery isn't the solution either. uBlock's default deny mode is for the really insane (IE: me). Mix that with NoScript and you don't need any additional blockers, and in theory you don't even need NoScript.