The first song of theirs that caught my ear and has lasted since I first heard them about five years ago has been "At Least That's What You Said", the opening track on "A Ghost is Born". I'm a sucker for a big guitar sound, and the solo that last most of the song carries a dissonance between the huge, angry tone and melodies that explore a range of anger, panic, and insecurity that defines what some of Wilco's music means to me, and it opened up a lot of music in the noise genre for me. Tweedy said the solo was a musical representation of one of his panic attacks.
Yep, that crunchy guitar is fantastic. Great build, love it. Good call on an awesome version too. I always enjoy seeing Tweedy performing a guitar solo, it's a somewhat rare thing but he sounds great with some Nels compliments.