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comment by OftenBen
OftenBen  ·  559 days ago  ·  link  ·    ·  parent  ·  post: Pubski: April 15, 2020

So your final unit measurement is something like estimated # of vesicles per mL?

How do you approach patient dosing?

b_b  ·  559 days ago  ·  link  ·  

Yes that is the unit. The dosing here is obviously sort of a guess, because there's no animal testing to fall back on. We've done some dose ranging in other disease models, so we're kind of going by that plus some extra for a fudge factor. I've done enough tox work that I have a lot of confidence in the safety, so I don't think overdosing is a problem beyond waste. The lung is one of the prime targets for this and similar therapies, so hopefully we'll see an effect. The bar is low, so any bit will help.

OftenBen  ·  559 days ago  ·  link  ·  

I cant wait to hear results.

As someone who may be on the receiving end of such a thing before long, Thanks for your hard work and persistence.

b_b  ·  559 days ago  ·  link  ·  

First thing's first, gotta get the feds on board