a thoughtful web.
Good ideas and conversation. No ads, no tracking.   Login or Take a Tour!
comment by mk
mk  ·  1484 days ago  ·  link  ·    ·  parent  ·  post: Pubski: March 25, 2020




b_b  ·  1484 days ago  ·  link  ·  

I bought skullcap like 3 weeks ago :)

I just had a call from a doc asking me if I wanted to manufacture some experimental drug (EV-based) to treat severe patients. It took me like 1 second to say yes. Now I'm gonna spend the rest of the day trying to write an emergency research IND.

mk  ·  1484 days ago  ·  link  ·  

If you want to try autologous blood EVs, let me know. Actually donor too. Takes 15 min after the draw.

kleinbl00  ·  1484 days ago  ·  link  ·  

Wanna give us the highlights?

mk  ·  1484 days ago  ·  link  ·  

    Furin activity exposes the binding and fusion domains, essential steps for the entry of the virus into the cell. Since the S- glycoprotein of all coronaviruses contains a similar furin cleavage site, it is plausible that the activity of this enzyme is essential for the zoonotic transmission of many coronaviruses, including Covid-19 enveloped by a MERS-CoV and Sars-CoV S glycoprotein containing a furin cleavage site.

    ...

    In these perspectives, likely, targeting furin might be an option for the prevention or treatment of Sars-CoV2 infection.

So yeah. Maybe inhibiting furin will work. The author theorizes it might help even more so in patients with heart issues.

kleinbl00  ·  1484 days ago  ·  link  ·  

I'm a believer. As a side benefit it's helping me sleep like a fucking log.

Now figure out what's in this magical panacea. It's the turbo-death pill my wife has been giving everyone when they get or start to get sick and it fucking works. The "I feel like shit" dose is 3 pills three times a day for three days and I tell you what I'm ready to try running again tomorrow and I'm on Day Two.

mk  ·  1484 days ago  ·  link  ·  

LOL it's like everything that everyone's grandmother told them to take when they are sick, but in one pill.

kleinbl00  ·  1484 days ago  ·  link  ·  

A pill that goes down sideways and gives you cayenne burps but fuckin' hell it's like Tamiflu for everything