She will lose in the Primaries. She is what in 2020? 73? 74? If the Democrats are insistent on running a woman for President, they have an embarrassment of talented women worthy of nominating and fighting for. Assuming that she stays healthy, sure, run again. Or instead she can be the deal maker and the fund raiser to rally the base and get someone who can beat Trump elected.
Two years is a long time, and she is not a young woman. A Campaign against a crowded Primary field will be brutal on her just based on her age.