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comment by Devac
Devac  ·  237 days ago  ·  link  ·    ·  parent  ·  post: We made a video for Forever Labs -- I dig it.

Well, I'm sold. It's a great and informative video.

I have a question, though. In Poland we have a DKMS Fundation (Dawcy Komórek Macierzystych i Szpiku - Donors of Stem Cells and Bone Marrow) that performs a procedure that seems similar to what you guys are doing (here are the details in English). Is it actually similar or am I confused due to my layman knowledge of medicine?




mk  ·  237 days ago  ·  link  ·  

We use an aspiration, which is a direct draw of a small amount of bone marrow. Mobilization (the process used by DKMS) is more expensive and time-consuming, and doesn't capture the entire bone marrow niche. That said, if you are donating marrow for a transplant, you want a large number of hematopoietic stem cells (HSCs), and without expanding them in a lab, mobilization is an easier way to get a large enough number.

It's our goal to collect and store a sufficient number of cells (HSCs, but also bone marrow mesenchymal stem cells, endothelial progenitor cells, and others) that can be expanded for many different uses in the future. You could take what we collect and use it for a BM transplant, but it may require expansion of the HSCs first, or a longer engraftment period.

Devac  ·  237 days ago  ·  link  ·  

So just to make sure I'm getting this correctly: DKMS is interested only in a subset of cells for a very specific purpose, whereas FL takes everything in order to have a more versatile selection of stem cells? I think that I got it, thanks. :D

mk  ·  237 days ago  ·  link  ·  

Yes, that's it.

Devac  ·  237 days ago  ·  link  ·  
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