I dunno, plenty of people are already in the 'increased discomfort' phase right now. A recession can only make that worse. Also, I'm reading Disrupted right now. You're right, I think several of the lines in the show were taken straight from the book.
The rush out of the coastal states is going to be a tsunami of people who have been saying 'fuck the flyover states' for a generation. Then they are going to realize that a huge tract of the nation where people can actually afford to live don't want a ton of SV and Brooklyn rejects. I remember reading people in Portland, OR whining about all the dan Californians moving north. The next migration is going to make that look like a holiday weekend.
Or currently: the people in Portland whining about the Californians moving north, the people in Seattle whining about the Californians moving north, the people in Tacoma whining about the Seattleites moving south and the Californians moving north, and the people in Eugene/Olympia/Spokane not really being affected...yet.