My reaction to people who are outside the norm -- gay, lesbian, transgender, whatever... is to just accept it and move on. I really don't give a damn whether you're a man, woman, or a trigendered pyrofox(well, calling yourself a trigender pyrofox would probably get a laugh from me. I'm pretty open-minded but crap like that is where I draw the line). Your identification doesn't tell me anything about you as a person, except maybe that you're off-limits for dating or that you've got a different emotional mindset from me.
And, like ViHart, I tend to cynically assume that people are using their identities as an attention-getting tool. Caitlyn Jenner leaves a bad taste on my mouth because I feel she cashed out on her identity, even if her real motivations are completely different. I guess I'm just wired to assume that everyone thinks the same way I do.