What do you own that, in your mind, cannot be replaced? For the sake of discussion, let's assume that all living things are safely accounted for.
I'll start: For me it would be my acoustic guitar. It is a 1976 Gibson J50. It's not the prettiest looking or sounding guitar but it has sentimental value. It's the guitar that my father in law gave me after marrying his daughter. He and his wife used to play it for my wife when she was a girl. Unfortunately, my wife's mother died when she was young. I never had the chance to meet her but playing this guitar makes me feel a bond to her.
I've recorded two (soon to be 3) albums with it and played countless shows with it. It's been dropped on stage, left behind at the venue etc but it always finds its way safely home.
That's what I'd grab. How about you?