The latest work extends this line of evidence by looking at specific peptide sequences from alpha-synuclein, which is a protein famously noted to be aggregated in the neurons of Parkinson’s patients. It turns out that T-cells from such patients (and not from controls) recognize these peptides, and this process appears to drive a cytotoxic immune response. This would tie in very well with the MHC genetic connections, and may well be putting us towards a better, more comprehensive explanation of the whole disease.

This is relevant to my interests.



posted by thundara: 143 days ago